Mid 2011, a new proof of the efficiency of Matrixyl® 3000, the famous peptide blend, was made available. This time, it was its ability to help repair the UV damage-prone papillary dermis that was demonstrated.
The papillary dermis, located just under the dermis/epidermis junction (DEJ), is more fragile than the reticular dermis and is intensely affected by photo ageing. Papillary fibroblasts are fundamental to promote epidermal morphogenesis and wound healing that is why papillary dermis repair delivers visible anti-wrinkle benefits.
In vivo studies have revealed the positive matrix reinforcing effect of Matrixyl® 3000 by measuring the SLEB density (Subepidermal Low Echogenic Band that corresponds to the papillary dermis). A significant improvement corresponding to a gain in age of 1.8 years is visible in just one month, and confirmed after 2 months: the photo-induced ageing is then delayed by 5.5 years.
Another analysis of the papillary dermis by confocal laser microscopy has shown that Matrixyl® 3000 helps reduce the fibre fragmentation and notably supports the reconstruction of the papillary dermal fibre network.
A complementary approach is confirming Matrixyl® 3000’s repairing effect of the cutaneous damages of ageing. Now it is its ability to reverse chronological ageing that has been demonstrated with both in vitro and ex vivo studies.