2011: New in vivo test reveals age gain by 2 years in just 1 month

Mid 2011, a new proof of the efficiency of Matrixyl® 3000, the famous peptide blend, was made available. This time, it was its ability to help repair the UV damage-prone papillary dermis that was demonstrated.

The papillary dermis, located just under the dermis/epidermis junction (DEJ), is more fragile than the reticular dermis and is intensely affected by photo ageing. Papillary fibroblasts are fundamental to promote epidermal morphogenesis and wound healing that is why papillary dermis repair delivers visible anti-wrinkle benefits.

Young papillary network
Young papillary network 
 Photo damaged fragmented papillary network
Photo damaged fragmented papillary network  

In vivo studies have revealed the positive matrix reinforcing effect of Matrixyl® 3000 by measuring the SLEB density (Subepidermal Low Echogenic Band that corresponds to the papillary dermis). A significant improvement corresponding to a gain in age of 1.8 years is visible in just one month, and confirmed after 2 months: the photo-induced ageing is then delayed by 5.5 years.

SLEB T0
SLEB T0
SLEB T2 months
SLEB T2 months

Another analysis of the papillary dermis by confocal laser microscopy has shown that Matrixyl® 3000 helps reduce the fibre fragmentation and notably supports the reconstruction of the papillary dermal fibre network.


2013: New study confirms previous findings

A complementary approach is confirming Matrixyl® 3000’s repairing effect of the cutaneous damages of ageing. Now it is its ability to reverse chronological ageing that has been demonstrated with both in vitro and ex vivo studies.



First, Matrixyl® 3000 has been shown to regulate the expression of well-known (SA β-galactosidase) and recently discovered (progerin) markers of senescence. Progerin is an altered form of the lamin A protein (lamins are key proteins in the skin’s regenerative process). With age, progerin's expression rises, as well as the skin tissue disorganisation. Matrixyl® 3000 does not only reduce the SA β-galactosidase activity, but it also reduces the progerin's expression while preserving the expression of the normal form lamin A.
progerin
Progerin

Then, immunohistochemistry analysis of skin sections (ex vivo study) has proved that Matrixyl® 3000 significantly stimulates synthesis of Collagen-I, -IV, -VII, -XVII and Nidogen-I proteins. While these proteins of the dermis and dermal-epidermal junction usually decrease with age, Matrixyl® 3000 rejuvenates the dermal structure and tends to make ageing skin behave like young skin.

Matrixyl 3000 - col VII - placebo
Collagen VII - Placebo
Matrixyl 3000 - col VII - M3000
Collagen VII - Matrixyl® 3000 3%
Matrixyl 3000 - col I - placebo
Collagen I - Placebo
Matrixyl 3000 - col I - M3000
Collagen I - Matrixyl® 3000 3%

Matrixyl® 3000 restores skin’s metabolism of youth. These innovative tests and claims give you one more reason to claim “Matrixyl® inside” on your products. 


To know more about these new tests, please visit the Matrixyl® 3000 product detail page (you will need to be logged to our extranet access the full data). You can also contact us to receive samples or for more info about the “Matrixyl® inside” programme.