The Matrikines success story

What is the secret behind the “soft” concept of Matrikines, how does it work and what can be done to improve it even further?

Horace in his Odes (vol. III) said it all when he spoke of the ‘injuries of time’. Wrinkles and dry skin and all their consequences are the ‘wounds’ that time inflicts on our skin; the sun and the environment only accelerate the process. So wound healing became the focus of tissue research, and the skin is a wonderful model to study wound healing.

Sederma is the first to have developed Matrikines, extracellular matrix-derived peptides, which are exact replicas of natural skin Matrikines. They act like cell messengers able to regulate the sequence of events required for skin repair (wound healing). More about Matrikines.

Matrikine peptides act from the inside to provide long term effects against skin ageing

Matrikine peptide is recognised by a cell membrane receptor and binds to the receptor. It triggers intracellular action that:

  • Promote tissue repair
  • Participate in wound healing
  • Stimulate macromolecule synthesis

More about Matrikine peptides:

Matrikine is a technical term proposed by Professor Maquart[1] describing oligo-peptides and protein fragments that are generated during the macromolecule breakdown process (phase one). Some of the fragments thus generated possess stimulating and signalling activity in a feedback loop, initiating the repair process of the tissue matrix, hence the name. These peptide fragments participate in the wound healing as natural, non-toxic, locally acting, highly potent messengers.

A number of different Matrikines has by now been identified, some with very specialized function: stimulation of collagen and fibronectin synthesis by GHK*, GQPR; chemotaxis by VGVAPG; cell binding and releasing activity by RGDS…

[1] MAQUART FX. et al, 1999, Régulation de l’activité cellulaire par la matrice extracellulaire : le concept de Matrikines, Journal de la Société de Biologie, 193, (4), p 423.
* The IUPAC One-letter code for Amino acids is used here to identify the peptide sequence.

Bibliographic references to go more in depth into the concept of Matrikines:

Gabriele D., Mas-Chamberlin C., Mondon P., Peschard O. and Lintner K., The role of chemotaxis in skin repair, Personal Care Asia Pacific, 5, 4, (2004)

Mas-Chamberlin C., Mondon P., Peschard O. and Lintner K., Matrikine technology and barrier repair: the Ultimate in anti-age skin care? Cosmetic Science Technology, (2004)

Mas-Chamberlin C., Mondon P., Peschard O. and Lintner K., Matrikines: a natural concept to replace retinoids in wrinkle treatment, Personal Care Asia Pacific, 5, 1, (2004)

Lintner K., Mas-Chamberlin C., Mondon P. and Peschard O., Wrinkle repair: a big step beyond retinol, Eurocosmetics, 11, 1, 25-28 (2003)

Lintner K., Promoting production in the extracellular matrix without compromising barrier, Cutis, Vol 70, 13-16 (2002)

Lintner K., Mondon P., Peschard O. and Mas-Chamberlin C., Cosmetic applications of a wound healing peptide, Journal of Cosmetic Science, 52 (1), 82-83 (2001)

Mas-Chamberlin C., Mondon P., Peschard O. and Lintner K., Collagen deficit and wrinkles: a new method to reverse cutaneous ageing, Eurocosmetics, 8, 3, 43 (2000)

Peschard O. and Lintner K., Biologically active peptides : from a laboratory bench curiosity to a functional skin care product, International Journal of Cosmetic Science, 22, 207-218 (2000)